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Polymyxin B
Product ID: P6809

Introduction

Description: An antibiotic used with PhytoSelect Medium (P6800) for the selection of Ralstonia solanacearum and other plant pathogens.

Min. Potency = >6000 u/mg
1 MU = 1 Million Units
1G = >6 MU
5G = >30 MU
25G = >150 MU

Solubility Water
Physical Form Solid
Storage Temp. 2-6 C
UPC / SKU P6809
CAS NUMBER 1405-20-5
Formula Weight 1385.61
Formula C55H96N16O13 * 2H2SO4
Synonyms Polymixin B
Storage Temp. 2-6 C
Tariff Code 3822.00.5090
Risk Info (R) 36/37/38
Safety Info (S) 36-37-39
No information available

P6809 Polymyxin B Sulfate

Synonyms: Polymixin, Polymixin B
CAS: 1405-20-5
Formula: C55H96N16O13 • 2H2SO4
Mol. Weight: 1385.61
Properties
Form: Powder
Appearance: White to Off-White Powder
Application: Phytopathology, Seed Testing, Microbiology
Solubility: Soluble in Water
Storage Temp: 2-6°C
Typical Working Concentration: Varies with applications, should be determined by end user.

Application Notes
Active against gram negative bacteria. Acts against microorganisms by binding to and interfering with the permeability of the cytoplasmic membrane.

Can be used with PhytoSelect Basal Medium (Prod # P6800) and additional antibiotics to select for Acidovorax avenae and Ralstonia solanacearum (Kawanishi 2011). See table on next page for media formulation details.

References
Kawanishi T, T. Shiraishi, Y. Okano, K. Sugawara, M. Hashimoto, K Maejima, K Komatsu, S Kakizawa, Y Yamaji, H Hamamoto, K Oshima, S Namba (2011) New Detection Systems of Bacteria Using Highly Selective Media Designed by SMART: Selective Medium-Design Algorithm Restricted by Two Constraints. PLoS ONE Volume 6, Issue 1.

Morrison DC, Jacobs DM (1976) Binding of polymyxin B to the lipid A portion of bacterial lipopolysaccharides. Immunochemistry.13(10):813-8.

Yuan Z, Tam VH: Polymyxin B: a new strategy for multidrug-resistant Gram-negative organisms. Expert Opin Investig Drugs. 2008 May;17(5):661-8. Pubmed Zavascki AP, Goldani LZ, Li J, Nation RL: Polymyxin B for the treatment of multidrug-resistant pathogens: a critical review. J Antimicrob Chemother. 2007 Dec;60(6):1206-15. Epub 2007 Sep 17. Pubmed