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Penicillin G, Sodium Salt
Product ID: P777

Introduction

Description: An antibiotic derived from Streptococcus pnuemoniae.
Active against gram-positive and gram-negative bacteria. Activity against microbes is based on interference of cell wall synthesis.
See product info sheet for details.

Solubility Water
Physical Form Solid
Solutions Available P6767
Storage Temp. Room Temperature
UPC / SKU P777
CAS NUMBER 69-57-8
Formula Weight 356.4
Formula C16H17N2O4SNa
Synonyms (2S,5R,6R)-3,3-Dimethyl-7-oxo-6-[(phenylacetyl)amino]-4-thia-1-azabicyclo-[3.2.0]heptane-2-carboxylic Acid, Sodium Salt
Storage Temp. Room Temperature
Tariff Code 2941.10.2000
Risk Info (R) 42/43
Safety Info (S) 26-36/37/39
No information available

P777 Penicillin G, Sodium Salt

Synonyms: (2S,5R,6R)-3,3-Dimethyl-7-oxo-6- [(phenylacetyl)amino]-4-thia-1-azabicyclo- [3.2.0]heptane-2- carboxylic Acid, Sodium Salt; Benzylpenicillin.
CAS: 69-57-8
Formula: C16H17N2O4SNa
Mol. Weight: 356.4
Properties
Form: Powder
Appearance: White to Off-White Powder
Application: Plant Tissue Culture Antibiotic
Solubility: Soluble in Water
Storage Temp: Room Temperature
Stock Solution Storage Temp: -20 oC (It's recommended that stock solutions should be stored in small aliquots to prevent freeze-thaw effect)
Typical Working Concentration: Varies by application. Concentration should be determined by end user.
Other Notes: Average activity: 1603 µg/mg (see Certificate of Analysis for lot specific activity)

Application Notes
Pencillin G is a beta-lactam antibiotic with board spectrum of activity against Gram-positive bacteria, Gram-negative cocci and some bacteria, spirochaetes and actinomycetes.2 Its mode of action is to inhibit the final stage of bacterial cell wall synthesis by binding to and inactivating the transpeptidase during the peptidoglycan production.2,3

Minimum inhibitory concentration (MIC) of penicillin G has been reported for many bacteria. MIC of penicillin G for S. pneumonia and S. pyogenes is 128 µg/mL4, B. subtilis is 0.8 µg/mL, S. aureus is 0.34 µg/mL , E. coli is 0.56 µg/mL, P. flourescens is 1.34 µg/mL, and H. pylori. is 0.92 µg/mL.5

PhytoTechnology Laboratories® also carries Penicillin G Solution at 10 mg/mL (Prod. No. P6767) which can be used with our PhytoSelect Basal Medium (Prod. No. P6800) for the selection of Xanthomonas campestris.

Please Note: It is the sole responsibility of the purchaser to determine the appropriateness of this product for the specific plants that are being cultured and applications that are being used.

References

  1. Merck 13, 7165
  2. Martindale: The Complete Drug Reference, 35th ed., Paul S. Blake, Ed. (Royal Pharmaceutical Society, 2007), p. 189-190.
  3. Yocum, Rogers R., David J. Waxman, James R. Rasmussen, and Jack L. Strominger. 1979. Mechanism of penicillin action: Penicillin and substrate bind covalently to the same active site serine in two bacterial Dalanine carboxy peptidases. Proc. Natl. Acad. Sci. USA.Vol 76(6):2730-2734.
  4. Adiogo, Dieudonne, Valentine Ngum Ze, Fredeique Beyala, Hortense Gonsu Kamga, Marie Claire Okomo Assoumou, and Gerard Beyiha. 2013. Importance of Bacterial Resistance in Streptococcus pneumonia and Streptococcus pyogenes in the Center Region in Cameroon. African Journal of Pathology and Microbiology. 2:1-3
  5. Chen, J.H., G.Y. Cui, J.Y. Liu, and R.X. Tan. 2003. Pinelloside, an antimicrobial cerebroside from Pinelliaternata. Phytochemistry. 64:903-906