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PhytoTechnology Laboratories

Product ID: C380


Description: Cefotaxime is a 3rd generation cephalosporin and it is highly effective against gram-negative bacteria. Cefotaxime is often used in transformation of plant species for the elimination of Agrobacterium tumefaciens.
See product info sheet for more information.

Solubility Water
Physical Form Solid
Storage Temp. 2 to 6 °C
UPC / SKU C380
CAS NUMBER 64485-93-4
Formula Weight 477.4
Formula C16H16N5O7S2Na
Synonyms (6R,7R)-3-[(Acetyloxy)methyl]-7-[[(2Z)-(2-amino-4-thiazolyl)
oct-2-ene-2-carboxylic Acid
Storage Temp. 2 to 6 °C
Tariff Code 2941.90.1010
Risk Info (R) 42/43-36
Safety Info (S) 26-36/37/39
No information available

C380 Cefotaxime, Sodium Salt

Synonym: (6R,7R)-3-[(Acetyloxy)methyl]-7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl] amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid, Sodium Salt
CAS: 64485-93-4
Formula: C16H16N5O7S2Na
Molecular Wt: 477.4
Form: Powder
Appearance: White to Cream Powder
Application: Plant Tissue Culture Antibiotic
Solubility: Soluble in Water 
Storage Temp: 2 to 6°C
Typical Working Concentration: 50 to 250 mg/mL
Storage Temp of Stock Solution: Aqueous solution at a pH 4.5-6.2 is stable for 7-14 days when stored at 2 to 6°C. Recommended long term storage at -20°C (i.e., non-frost freezer).

Application Notes

Cefotaxime is an inhibitor of cell wall synthesis and chemically related to penicillin. It is highly effective against Gram-negative bacteria1. Cefotaxime is often used in transformation research for the elimination of Agrobacterium tumefaciens. Additionally, cefotaxime also has stimulatory effect. It is founded that addition of cefotaxime to medium enhances shoot organogenesis in vitrofor many plants (apple, barley, grain, maize, etc.).2,3

A concentration of 90 µg/mL is recommended to achieve microbe toxicity. Cefotaxime concentrations should not exceed 100 µg/mL in order to avoid toxicity for plants (though plant toxicity may be higher or lower than 100 µg/mL for different plant species).

Please Note: While PhytoTechnology Laboratories® tests each lot of this product with two or more plant cell/ tissue culture lines, it is the sole responsibility of the purchaser to determine the appropriateness of this product for the specific plants that are being cultured and applicationsthat are being used.


  1. Merck 13, 19462.
  2. Danilova, S.A., Yu. I. Dolgikh. 2004. The stimulatory effect of the antibiotic cefotaxime on plant regeneration in maize tissue culture. Russian Journal of Plant Physiology. 51. pp 559 -562.
  3. Rao, A.m., K. Padma Sree, and P.B. 1995. Kavi Kishor. Enhanced plant regeneration in grain and sweet sorghum by asparagines, proline and cefotaxime. Plant Cell Reports. 15. pp 72-75.