G418 Sulfate Product ID: G810
Introduction
Description: G418 is an aminoglycoside antibiotic. It is a derivative of neomycin and inhibits protein synthesis.
Synonym: Geneticin®
See product info sheet for more information.
| Solubility |
Water |
| Physical Form |
Solid |
| Storage Temp. |
2 to 6 °C |
| UPC / SKU |
G810 |
| CAS NUMBER |
108321-42-2 |
| Formula Weight |
692.7 |
| Formula |
C20H40N4O10 • 2H2SO4 |
| Synonyms |
Geneticin® |
| Storage Temp. |
2 to 6 °C |
| Tariff Code |
2941.90.1010 |
| Risk Info (R) |
61-20/21/22 |
| Safety Info (S) |
22-36/37/39-45 |
No information available
G810 G418 Sulfate
| Synonyms: |
Geneticin® |
| CAS: |
108321-42-2 |
| Formula: |
C20H40N4O10 . 2H2SO4 |
| Mol. Weight: |
692.7 |
| Properties |
|---|
| Form: |
Powder |
| Appearance: |
White to off-white powder |
| Application: |
Plant Tissue Culture Antibiotic |
| Solubility: |
Soluble in Water |
| Storage Temp: |
2 to 6 °C |
|
Protect from Light. |
Application Notes
G418 is an aminoglycoside antibiotic. Unlike other aminoglycoside, G418 is more potent because it contains a hydroxyl function at C-6' position rather than an amino function. It binds directly to the 80S ribosomal subunit and inhibits protein synthesis of eukaryotic cells.1 G418 is effective against aerobics and facultative Gram-negative bacilli, and some Gram-positive bacteria.
In molecular biology application, G418 sulfate is often used as a selection agent.2-4
Please Note: It is the sole responsibility of the purchaser to determine the appropriateness of this product for the specific plants that are being cultured and applications that are being used.
References
- Marie-Paule Mingeot-Leclercq, Youri Glupczynski, and Paul M. Tulkens. 1999. Aminoglycosides: Activity and Resistance. Antimicrob Agents Chemother. Vol 43(4). Pp. 727-737.
- Xie, D. and Y. Hong. 2002. Agrobacterium-mediated genetic transformation of Acacia mangium. Plant Cell Reports. Vol 20(10). Pp. 917-922.
- P. A. Lazzeri, R. Brettschneider, R. Lührs, and H. Lörz. 1991. Stable transformation of barley via PEG-induced direct DNA uptake into protoplasts. Theoretical and Applied Genetics. Vol 81(4). Pp. 437-444.
- Christine Lang-Hinrichs, Dietmar Berndorff, Carsten Seefeldt, and Ulf Stahl. 1989. G418 resistance in the yeast Saccharomyces cerevisiae: comparison of the neomycin resistance genes from Tn5 and Tn903. Applied Microbiology and Biotechnology. Vol 30(4). Pp. 388-394.
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