Hospital-acquired infections (HAIs) are on
the rise despite efforts to decrease them. HAIs cause an estimated 100,000
deaths annually and account for up to $45 billion in health-care costs. In
USA only about 2 million patients get affected with HAI out of which
around 90,000 die. HAIs are a significant cause of morbidity and
mortality. At any given time, about 1 in every 20 inpatients has an
infection related to hospital care. These infections cost the U.S. health
care system billions of dollars each year and lead to the loss of
thousands of lives. In addition, HAIs can have devastating emotional,
financial and medical consequences. It has been estimated that an
incidence of hospital acquired infection increases the hospital care cost
of a patient by $10,375 (USD) and it increases the length of stay by 3.30
days, and that a disproportionately higher portion of the cost is
attributable to Medicare. Even in India average cost for treatment of HAI
is Rs. 704,175±57,804/-.Adding fuel to the fire, bacteria increasingly are
becoming resistant to last-resort drugs.
Antibiotics has been a golden bullet in the
treatment of various diseases caused by microbial infections so far but
not anymore, we have entered a post antimicrobial era. Misuse and overuse
of antibiotics over the years have rendered them powerless to fight
against infections.
A "superbug"-deadly, antibiotic-resistant
bacterium are the first outcome of over exposure and frequent use of
antibiotics, gene mutations and gene shuffling have resulted in the
formation of new proteins that can counteract the antibiotic's mechanism
of action.
A new strain of the drug-resistant
"superbug" MRSA has been found in British cows, and it appears to be
spreading to people, reports the BBC.The study published in the journal
Lancet Infectious Diseases, warned that a gene - named New Delhi-Metallo
-1 (NDM-1) had been found in bacterial infections, which made them
resistant to almost all antibiotics, with "an alarming potential to
spread". Of 29 cases in Britain examined in the study, at least 20 of the
patients had visited India and Pakistan in the last year, and most had
undergone surgery while they were abroad.
People in three states were fallen prey to
a new breed of superbugs, bacteria carrying a gene that makes them
impervious to virtually any antibiotic. All three patients had recently
received medical treatment in India, where the gene was first discovered,
and has become widespread, the AP reports.
A hospital-acquired infection, development
is favoured by a hospital environment, such as one acquired by a patient
during a hospital visit or one developing among hospital staff. Such
infections include fungal and bacterial infections and are aggravated by
the reduced resistance of individual patients, specially the individuals
with weak immune system such as people having:
- Adrenal insufficiency
- Diabetes mellitus
- Febrile neutropenia
- Human immunodeficiency virus infection
- Organ transplantation
- Acute glomerulonephritis
- Polyarteritisnodosa
- Microscopic polyangiitis
- Autoimmune diseases
- Inflammatory diseases
- Chemotherapy, HIV, and Lupus
- Malnutrition
- Aging
- Cancer
- Malnutrition
- Aging
- Cancer
- Neonatal stage
Microorganisms involved in most nosocomial infections:
Microorganism |
Percentage of total infection |
Percentage resistant to antibiotics |
Infections caused |
Coagulas-negative staphylococci |
15% |
89% |
Most common to cause sepsis |
Staphylococcus aureus |
15% |
50% |
Most frequently cause of pneumonia |
Enterococcus spp. |
10% |
4-71% |
Most common cause of surgical wound infections |
E. coli, Pseudomonas aeruginosa, Entrobacter, and Klebsiella
pneumonia |
23% |
3-32% |
Pneumonia and surgical wound infection |
Clostridium difficile |
15-25% |
Not reported |
Causes nearly half of all nosocomial diarrhea |
Candida albicans (fungus) |
7% |
Not reported |
Urinary tract infection and sepsis |
Other gram-negative bacteria (Acinetobacter, Citrobacter,
Haemophilus) |
7% |
Not reported |
Urinary tract infections and surgical wound
infections |
Under a condition where a
superbug/multidrug resistant microbe entered the host having a compromised
immune response, the results will be sure shot devastating on both
financial and emotional grounds. Thus hospitals are required to have a
high level of sterility throughout their premises as they are the epitome
of hygiene and sanitation. Despite this unified concern, the data from
individual countries shows that infectious disease priorities do vary
widely across the world. For example in India the top three concerns are
illnesses that cause seasonal colds (47.3 percent), skin infections (37.1
percent) and seasonal flu (31.9 percent).
Our product ATZ-Touch will form an
impermeable cover upon application, which will remain on the surface for
long duration. Since ATZ-Touch is not consumed during the mode of action
it protects the surface from microbes for long duration of time. ATZ-Touch
is not involved in chemical kill but mechanical there is no chance of
development of superbugs against this technology, because of this property
ATZ-Touch is effective against almost every microbe. ATZ-Touch is even
effective against multiple drug resistant microbes such as MRSA, NDM-1,
etc. The protective covering through ATZ-Touch not only makes things
sterile but will also avoid cross-contamination, helping in reducing the
nosocomial infections.Click on the link for more information about
ATZ-Touch and for FAQs.
Contaminated linen is generated by
hospitals, care homes, nursing homes and similar facilities, as well as in
the home care setting; anywhere that care of the sick and infirm is
undertaken. The nature of laundry soiling depends on the source, and at
the most extreme levels, e.g. in hospital and nursing home environments,
is likely to include blood, wound exudates, sputum, saliva, sweat and
urine, as well as vomit and faeces. It is also important to recognise that
bloodstained body wastes such as urine may also serve as a potential
source of infection.
Investigators at Denver Health performed a
randomized, controlled trial to assess the degree of bacterial
colonization and contamination by MRSA on work clothes. The main findings
of the study were: No difference in overall bacterial counts between the
white coats and the uniforms No difference in MRSA contamination (16% for
white coats vs. 20% for uniforms).
Current recommended treatments to ensure
cleaning and disinfection of used (soiled and foul) linen
- A 65ºC temperature hold for a minimum of 10 minutes; or
- 71ºC for not less than 3 minutes.
- Mixing time must be allowed to ensure heat penetration and assured
disinfection. Recommended treatment to ensure disinfection of infected
linen (mainly applicable to the healthcare setting)
- Storage of infected linen must be done in a secured area, prior to
washing.
- The same wash temperature profile as used for used (soiled and foul)
linen is thought sufficient to inactivate HIV, but the evidence is less
certain for hepatitis B. The wash temperature, coupled with the dilution
factor, should render linen safe to handle on cycle completion.
Current recommended treatment to ensure
disinfection of heat labile linen
- These items need to be washed at ~40ºC, so the wash temperature is
insufficient to disinfect, and chemical alternatives are required.
- Addition of hypochlorite may be possible, but efficacy may be
reduced by the presence of soiling, detergents and alkalis in the main
wash.
- Disinfection with hypochlorite is only reliable if the linen can
tolerate its addition and if sodium hypochlorite is added during the
penultimate rinse of the cycle.
- A final concentration of 150 ppm available chlorine must be achieved
for a minimum of 5 minutes exposure time.
- Laundering contaminated items in the community setting.
List of the microorganisms surviving on
hospital textiles after laundering
Described laundering conditions |
Added disinfection agent or bleach |
Surviving microorganism |
10 min at 60ºC |
No |
Enterococcus faecium |
10 min at 60ºC or 3 min at 71ºC |
No |
Certain strains of Enterococcus faecalis and
Enterococcus faecium |
less than 10 min at 60ºC |
3 mL Peroxyacetic acid/ kg textiles |
Enterococcus faecium, Staphylococcus aureus, Pseudomonas
aeruginosa andEnterobacter aerogenes |
20 min at 30ºC |
10 mL Sodium hypochlorate/kg textiles or 12.5 mL peroxyacetic
acid/kg textiles |
Enterococcus faecium and Enterobacter aerogenes |
43 min at 30ºC |
10 mL Sodium hypochlorate/kg textiles |
Enterococcus faecium |
13 min at 49ºC |
Added chlorine bleach (without specifications) |
Staphylococcus aureus and Klebsiella pneumoniae |
66ºC |
Added chlorine bleach cycle (without specifications) |
Staphylococci, Klebsiella, and Enterobacter species |
8 min at 47.8ºC |
0.58 Chlorine bleach/kg |
Predominantly aerobic bacteria, staphylococci and
total coliforms |
77.2ºC
| 0.11 Chlorine bleach/kg |
22.2ºC |
Low temperature bleach (without specifications) |
Predominantly Enterobacteriaceae, Pseudomonadaceae
and Staphylococcusspecies |
71.1ºC
| High temperature bleach (without specifications) |
Typical program for hospital bed linen |
50 ppm Chlorine, 54 ppm peracid, 100 ppm peroxid |
Clostridium difficile spores |
ATZ-FABrich is a must to have product for
hospital industry, when mixed with the laundry during washing ATZ-FABrich
forms a protective layer onto the cloth and protect it from microbial
contamination for next 40 washes. This active shield mechanically kills
the invading microbe and thus keeps it sterile, ATZ-FABrich makes cloth
safe for both patient and the service provider.
Surgical room are required to be sterile at
all the time during and post a surgical operation. Single contamination
can easily put the reputation of the organisation and the life of the
patient at stake. According to the study the patients' charts/files in the
ICU were usually contaminated with pathogenic and potentially pathogenic
bacteria,several bacteria had been isolated from the charts, including
multidrug-resistant Acinetobacter baumannii, Stenotrophomonas maltophilia,
and Klebsiella pneumoniae, same bacteria were isolated from patients.
Contaminated charts can serve as a source for cross-infection. A person
can easily contaminate the equipment in the surrounding or where ever
he/she may touch like patient's body. Conventional methods that use
alcohol based disinfectants and sanitisers are not effective against many
microbial stains. And most of the chemicals have led to the microbial
adaptation to form super bugs, hard to counteract.
Examples of Medical Devices which
require high level of sterility but hard to make sterile.
- Bronchoscopes
- GI endoscopes
- Laryngoscopes
- Nasopharyngoscopes
- Cystoscopes
- Respiratory therapy and anesthesia equipment
- Tonometers
- Vaginal specula
- Endocavitary probes
- Prostate biopsy probes
- Infrared coagulation devices
|
- Diaphragm fitting rings
- Esophageal manometry probes
- Anorectal manometry catheters
- ECG leads and cables
- Electronic thermometers
- Blood pressure cuffs
- Stethoscopes
- Pulse oximetry sensors
- Some ultrasound transducers
- Bedpans
- Blood glucose meter
|
Multiple studies have demonstrated that
portable healthcare equipment, such as stethoscopes, tourniquets,
sphygmomanometer cuffs, electronic thermometer handles, otoscopes and
pagers also become contaminated, like hands, and can serve as a potential
vector for antibiotic-resistant pathogens to patients, either via direct
contact or by contamination of clinician's hands.Click on the link for
more information about ATZ-Mobi friend
Our product ATZ-Touch can easily overcome
these problems, since during application it forms a fog in the section
where it is applied, this leads to a cover on each and every object in the
surrounding. Thus covering every part of the equipment, objects, which are
hard to sterilize.ATZ-Touch will not only sterilize the object but it will
protect it for next 30 days from any kind of microbial contamination. Thus
ATZ-Touch will make and keep your surrounding sterile for 30 days round
the clock.
Gloves that are being used by the staff
provides protection only to the person wearing them, but they readily
participate in the cross contamination of microbes. Clinician's and other
staff members should use ATZ-Dew once a day to make and keep their hands
sterile for 24 hours, this will not only protect the them but will also
help in avoiding the cross contamination of microbes. Click on the link
for more information about ATZ-Touch and for FAQs.Click on the link for
more information about ATZ-Dew
Research have mentioned that shoe can be a
heaven for microbial growth, inside of shoe is a dark and warm place,
sweat glands in our foot provides the required moisture for microbes to
thrive in, smell from the socks are symptoms of bacterial growth and one
should be serious about their hygiene if they can smell it.Since there has
been an increase in the number of individuals with diabetes, there has
been a huge increase in the number of individuals suffering from diabetic
foot, a medical condition where sores are developed due to limited
peripheral neuropathy, vascular insufficiency and diminished neutrophil
function.Patient with diabetic foot have to take special care of their
foot as negligence could lead to amputation of the organ. Diabetic foot
patients have to examine their footon frequent basis, always keep it dry,
and wear clean and soft socks, to keep their foot under good and healthy
condition. Despite of these efforts there has been cases where the
individual got infected and the condition became acute.More than 60
percent of nontraumatic lower-limb amputations occur in people with
diabetes.
However these conditions can be avoided
with the help of our product ATZ-Dew which will protect the foot from any
invading microbe and will keep protecting for next 24 hours.ATZ-FABrich
can be used to wash the socks and other garments to protect the foot and
the individual for longer duration. ATZ-Touch can be applied inside and
outside the shoe, this will avoid any growth of the microbe in the shoe.
Thus this combination will provide the individual a sure shot protection
against and will help in quick recovery of the wound.
Mobile phones have been proved to be a
great source of contamination. They are one of the most of frequently used
electronic gadgets by everyone in the present world. Even hospital staff
do carry a phone with them, there is a high probability of transmitting
the disease among others through the phone, or there could be a chance
that a staff could carry a pathogenic or life threating microbe back home
to their loved ones. Our product ATZ-Mobi friend provides the protective
cover to your mobile and other electronic items and make sure that neither
you nor your loved ones come in contact with any microbe through your
phone, once applied it will keep your phone sterile for next 30 days and
will not allow growth of any microbe.
Department |
What product to use |
How it will benefit |
Accident and emergency Anaesthetics Breast
screening Cardiology Critical care Diagnostic
imaging Discharge lounge Ear nose and throat (ENT) Elderly
services department Gastroenterology General
surgery Gynaecology Haematology Maternity
departments Microbiology Neonatal
unit Nephrology Neurology Nutrition and
dietetics Obstetrics and gynaecology units Occupational
therapy Oncology Ophthalmology Orthopaedics Radiotherapy Renal
unit Rheumatology genitourinary medicine Urology |
ATZ-Touch
ATZ-Dew
ATZ-FABrich
ATZ-Mobi friend |
- ATZ-Touch sterilize the room along with all equipment and
keeps it sterile
- Effectively sterilize and keep patient contact points like,
door knobs, furniture, inquiry section, hospital machines
(radiography, mammography, angiography, CT scanning, MRI
scanning) sterile for 30 days.
- Effectively sterilise all of surgery equipment and keep them
sterile for 30 days.
- ATZ-Dew sterilize staff's hand and protect them for next 24
hours from contaminating objects and patient by forming an active
glove.
- ATZ-FABrich, keeps staff's apron and Lenin of the organization
sterile for 40 washes. Thus avoiding any kind contamination to
patients specially ones having week immunity like HIV patients,
neonatal, patients on immune suppressants.
- ATZ-Mobi friend, keeps the electronic gadgets like phones,
tablets, laptop screens, key boards sterile for 30days as they
have been classified as a potential source of contamination.
|
Canteen plays a great role in filling the
appetite of hospital staff and visitors. If not managed properly a canteen
can be huge source of contamination.There has been various incidences
which have forced closer of the canteen and heavy penalty to the owner, in
a recent event food safety officials ordered the closure of the canteen on
the campus of the Peroorkada Government Hospital on charges of cooking and
serving food under unhygienic conditions, and for unhealthy maintenance of
surroundings. Hospitals being a hub for eliminating various microbes,
sometime serves as a reservoir of microbe. Any unhygienic practice in
cafeteria can lead to a huge number of HAIs and other difficult to treat
disease caused by superbugs.
Our product ATZ-Touch can be used to
protect everything in kitchen environment including utensils, preparation
desk, cutting and chopping tools, food containers, even walls and ceiling,
ATZ-Touch will form a protective layer on the device its applied and will
protect it from microbes for 30days during which microbial load will not
increase and thus will eliminate the risk of contamination. Our product
ATZ-Dew will provide anti-microbial protection to the hands of each and
every employee working in the kitchen. By the application of this product,
the need of washing hands every hour or so will be eliminated. Washing
chef's uniform and other clothing with ATZ-FABrich will provide another
protection from the microbes and will avoid any cross contamination.