|
| In Vitro Toxicology |
|
|
|
Metabolism Assays |
| |
|
|
Drug-Drug Interaction Studies |
|
|
Cytochrome P450 Induction |
|
|
Cytochrome P450 Inhibition |
|
|
In Vitro Absorption and Metabolism Models |
|
|
Flux rate determination and permeability constants |
|
|
Flux rate determination and permeability constants |
|
|
|
Cell Based Assays |
| |
|
|
Hemolytic Potential in Human Blood: Using human blood |
|
|
Hemolytic Potential in Rat, Dog, and Human Blood |
|
|
Optional Plasma and Serum Compatibility: |
| Compatibility is determined by adding the test article to plasma and serum individually and then assessing the occurrence or non-occurrence of precipitation or coagulation of plasma or serum protein |
|
|
|
lsoenzyme Analysis |
| |
|
|
Glucose-6-Phosphate Dehydrogenase (G6PD) |
|
|
Lactate Dehydrogenase (LD) |
|
|
Malate Dehydrogenase (MD) |
|
|
Nucleoside Phosphorylase (NP) |
|
|
Aspartate Aminotransferase (AST) |
|
|
Peptidase B (PepB) |
|
|
G-Protein Coupled Receptors (GPCR) |
|
|
cAMP Phosphodiesterase Assay |
|
|
Protein Kinase Assay (PK) |
|
|
|
Mutagenesis |
| |
|
|
COMET Assay! DNA Damage Assay |
|
|
Unscheduled DNA Synthesis (UDS) |
|
|
DNA Damage |
|
|
Sister Chromatid Exchange (SCE) |
|
|
Bacterial Gene Mutations |
|
|
Mammalian Gene Mutations |
|
|
Chromosome Aberrations |
|
|
Micronucleus (IVM) Test |
|
|
TK in Mouse Lymphoma Cells (L5178Y cells) |
|
|
1K in Human Lymphoblastoid TK6 Cells |
| |
o HGPRT
oCHO
oV79 cells
o L5178Y cells |
|
|
|
Toxicity Studies |
| |
|
|
Angiogenesis |
|
|
Apoptosis |
|
|
Proliferation |
|
|
Na!K AlPase Activity |
|
|
Ca AlPase Activity |
|
|
Histone acetylase! Deacetylase |
|
|
Tissue Marker Identity |
|
|
|
In Vivo Toxicology |
|
|
|
Safety/Toxicology |
| |
|
|
Acute Single Dose |
|
|
Acute Repeat Dose |
|
|
Inhalation (Microspray) |
|
|
Dermal Studies |
|
|
Acute Irritation Studies |
|
|
Sub-Chronic Toxicity |
|
|
Chronic Toxicity |
|
|
ADME/PK |
|
|
Immunotoxicology |
|
|
|
Immunogenicity / Antigenicity |
| |
|
|
Development of Anti-drug Antibodies (ADA) |
|
|
Vaccine Efficacy |
|
|
|
Biodistribution |
| |
|
|
PK |
|
|
QPCR |
|
|
Radio-labeling |
|
|
ADME |
|
|
Tumor Studies |
|
|
Genetic Toxicity |
|
|
Drug Efficacy Studies |
|
|
|
In Vivo Mutagenesis |
| |
|
|
Unscheduled DNA Synthesis (UDS) in rat and!or mouse liver |
|
|
COMET Assay! DNA Damage Assay in rodents |
|
|
Sister Chromatid Exchange SCE) |
|
|
Micronuclei Formation |
|
|
Cell Transformation |
|
|
Tumor Response |
|
|
|
Health Monitoring |
| |
|
|
Necropsies |
|
|
Serology |
|
|
Parasitology |
|
|
Bacteriology |
|
|
Mycology |
|
|
Mycoplasma |
|
|
Murine MAP-PCR |
|
|
Diagnostic PCR |
|
|
Water Microbiology |
|
|
|
Clinical Pathology |
|
|
Hematology |
| |
|
|
Complete Blood Count (CBC) |
|
|
Serum Chemistry |
|
|
Coagulation |
|
|
Blood Glucose |
|
|
Capillary Tubes |
|
|
|
Blood Chemistry |
| |
|
|
Electrolyte Balance |
|
|
Carbohydrate Metabolism |
|
|
Liver function |
|
|
Kidney Function |
|
|
Cardiac Function |
|
|
Lipid Panel |
|
|
Bone and Joint |
|
|
Anemia |
|
|
Other Markers |
|
|
|
Endocrinology |
| |
|
|
Diabetes |
|
|
Thyroid Disease |
|
|
Adrenal Dysfunction |
|
|
Fertility and Reproduction |
|
|
Bone ! Mineral Metabolism |
|
|
Auto-immune Diseases |
|
|
Other Bio Markers |
|
|
|
Urine and Fecal Analyses |
| |
|
|
Urine Analyses |
|
|
Fecal Analyses: |
|
|
Parasitological |
|
|
Microbiology |
|
|
|
Histopathology Services |
|
|
|
Histology |
| |
|
|
Frozen Sections |
|
|
Specimen Fixation |
|
|
Paraffin Sections |
|
|
Resin Sections |
|
|
Sample Preparation |
|
|
Fixative Reagents |
|
|
|
Experimental Pathology |
| |
|
|
Sentinel Screening |
|
|
Toxicology Assessment of Organs |
|
|
Morphometric Evaluation |
|
|
|
Immunohistochemistry |
| |
|
|
Avidin-Biotin Methods |
|
|
Alkaline Phosphatase |
|
|
Antigen Retrieval |
|
|
Medicated Retrieval |
|
|
Proteolytic Enzyme Digestion |
|
|
Sample Preparation |
|
| |
|
