Human Exosomes
ZenBio human pre-adipocytes are mesenchymal stem cells (MSC) isolated from human adipose tissue and characterized by their self-renewing capacity and ability to differentiate into chondrocytes, adipocytes, and osteocytes. This makes them attractive starting materials for tissue engineering and regenerative medicine applications.

Since few transplanted cells persist in vivo, the beneficial effects of cell therapy may lie in the secreted factors being the active component of this treatment. A key part of paracrine secretion is Exosomes, which are membrane vesicles that are stored intracellularly in endosomal compartments and are secreted when these structures fuse with the cell plasma membrane.
  • Exosomes contain protein, DNA, and RNA, thus making them an attractive vector of paracrine signals delivered by stem cells.
  • Exosomes may also be "loaded" with predetermined proteins and nucleic acid to achieve a desired effect (1).
  • Exosomes can be stored as an "off-the-shelf" product having the potential for circumventing many of the limitations of viable cells for therapeutic applications in regenerative medicine.
  • In vitro, exosomes from pre-adipocytes stimulate cell proliferation in a wound healing model.
  • In vivo, adipose-graft derived exosomes have been shown to be a promising tool for skin repair and remodeling (2)


All cells have been screened negative for HIV-1, HIV-2, HTLC-1, HTLV-2, Hep-B, Hep-C. Quality Control: All isolated and concentrated exosomes undergo protein, DNA, RNA quantitation.
Human Exosomes Control and Treated Photograph


Ordering Information:

Human Exosomes
Item Units Catalog#
Custom Exosome Isolation from Tissue or Cells. Available formats:

1)Isolated and concentrated fresh or frozen in DPBS
2)Fresh or frozen conditioned tissue culture media containing exosomes 		EACH CA-10


Technical Details

 Camussi G, et al., Review : Exosome/microvesicle-mediated epigenetic reprogramming of cells. Am J Cancer Res 1(1): 98-110, 2011

Pellon MA. Fat-graft derived exosomes: a promising tool for skin repair and remodeling. Poster presentation, Second International Meeting of ISEV (International Society of Extracellular Vesicles) 2013, Boston, USA, April 17th-20th, 2013